The American Society for Reproductive Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
CREDIT DESIGNATION STATEMENT
The American Society for Reproductive Medicine designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
Release Date: October 1, 2015
Reviewed and Updated in 2015
Expiration Date: September 30, 2018
Estimated Time to Complete Activity: 0.5 hours
NEEDS ASSESSMENT and IDENTIFICATION OF PRACTICE GAP
Genetics play an important role in male infertility. Azoospermia and severe oligozoospermia may be associated with genetic abnormalities. Numerical or structural chromosomal abnormalities can be detected in approximately 14% of men with severe spermatogenic impairment. Mutations in genes that encode proteins involved in spermatogenesis, development of the seminal ductal system, the reproductive endocrine axis and other systems involved in male reproduction, may lead to male infertility. Common genetic problems include microdeletions of the Y chromosome, cystic fibrosis gene mutations and chromosomal abnormalities. Genetic endocrine defects causing male infertility include disorders of androgen biosynthesis, metabolism and receptors, as well as hypogonadotropic hypogonadism. The area of genetics as related to male infertility has been identified as a physician practice gap by the ASRM CME Committee.
At the conclusion of this educational activity, participants should be able to:
1. List the genetic causes of male infertility, grouped by type of disorder (numerical or structural chromosomal disorder, gene mutation, etc.).
2. Identify the most common genetic causes of male infertility, including their prevalence, clinical presentation and impact on treatment options.
3. Describe the genetic testing included in the evaluation of male infertility and the indications for these tests.
This activity is designed to meet the educational needs of new and experienced clinicians, laboratory scientists and allied health professionals with an interest in the evaluation and treatment of the infertile male.
SUCCESSFUL COMPLETION REQUIREMENTS
Successful completion of this educational activity requires the learner to:
· View a course overview page, containing all CME and disclosure information, including acknowledgement of commercial support and disclosure of unlabeled use, prior to the start of the module.
· Complete a 10-question pre-exam. Learners should note any pre-exam questions answered incorrectly for clarification during module study.
· Be given the option of downloading a printed syllabus containing the presentation and narrative.
· Participate in the interactive activity: Audio narration is synchronized with PowerPoint presentation that can be advanced, stopped or reversed as desired.
· Complete a 10-question post-exam, with feedback of correct/incorrect answers, scoring a minimum of 70% in two attempts.
· Complete the evaluation survey.
· Print certificate of completion.