ACTIVITY TITLE: Primordial Germ Cells and Oogenesis
The American Society for Reproductive Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
CREDIT DESIGNATION STATEMENT
The American Society for Reproductive Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
Release Date: October 15, 2014
Expiration Date: October 15, 2017
Estimated Time to Complete Activity: 60 minutes
NEEDS ASSESSMENT and IDENTIFICATION OF PRACTICE GAP
Human ovum formation, growth, and maturation into functional gametes is a complex process. Personnel performing in vitro fertilization technologies need to have an understanding of the physiological mechanisms behind oocyte recruitment, including ovarian structure and function, oocyte development in vivo, the chromosomal makeup of oocyte structures in vivo. Laboratory personnel should also have a working understanding of the impact of in vivo and ex vivo hormonal exposure on oocyte development, and the hormonal environment of the ovary and developing oocytes under both conditions. The educational need for this activity was based on the 2011 gap analysis review by the ASRM CME Committee.
At the conclusion of this educational activity, participants should be able to:
1. Describe the origin, migration, proliferation, and identification of human primordial germ cells.
2. Discuss the growth and differentiation of a follicle.
3. Describe the process of meiosis in oogenesis.
4. Explain the interactions between the follicle and the oocyte.
5. Describe the process of oocyte growth, maturation, and ovulation.
This activity is designed to meet the educational needs of new and experienced laboratory scientists and allied health professionals involved in assisted reproduction.
SUCCESSFUL COMPLETION REQUIREMENTS
Successful completion of this educational activity requires the learner to:
· View a course overview page, containing all CME and disclosure information, including acknowledgement of commercial support and disclosure of unlabeled use, prior to the start of the module.
· Complete a 10-question pre-exam prior to each module. Learners should note any pre-exam questions answered incorrectly for clarification during module study.
· Be given the option of downloading a printed syllabus containing the presentation and narrative.
· Participate in the interactive activity by listening to the audio narration that is synchronized with the PowerPoint presentation; this can be stopped, reversed, or advanced as desired.
· After completion of the lesson, take a 10-question post-exam, with a minimum score of 70 percent correct in two attempts.
· Complete the evaluation survey.
· Print certificate of completion.
DISCLOSURES FOR PLANNERS AND FACULTY
Susan A. Gitlin, PhD: Nothing to Disclose
Michael Reed, PhD: Nothing to Disclose
Andrew R. La Barbera, PhD: Nothing to Disclose
Richard H. Reindollar, MD: Nothing to Disclose
Nancy Bowers, BSN, RN, MPH: Nothing to Disclose
Content Developers and Reviewers
§ Morgan Amick, BS: Nothing to Disclose
§ Anthony Anderson, DSc: Nothing to Disclose
§ Marlane Angle, PhD: Consultant: Previvo
§ C. Brent Barrett, PhD: Consultant: ReproSource Fertility Diagnostics
§ Charles Bormann, PhD: Nothing to Disclose
§ Bruce Carr, MD: Grant/Research: AbbVie, Medicines 360; Speakers Bureau: Shionogi, Noven, Pfizer
§ Marcelle Cedars, MD: Grant/Research: Nora Therapeutics; Ferring Pharmaceuticals
§ Grace Centola, PhD: Consultant: New England Cryogenic Center; Cryos International-NY, Central Park Fertility
§ Carli Chapman, MS: Nothing to Disclose
§ Ri-Cheng Chian, PhD: Other: Cooper Surgical/SAGE Company
§ Susan Crockin, JD: Consultant: BMS, Merck, Prometheus; Advisory Board: GSK, CoStim, Aveo; Speakers Bureau: Pfizer Canada, BMS
§ Judith Daar, JD: Nothing to Disclose
§ Erma Drobnis, PhD: Nothing to Disclose
§ Kathryn Go, PhD: Nothing to Disclose
§ Kay Graff, MS: Consultant: Steptoe Therapeutics; Employee: Pelton & Crane
§ Elizabeth Grill, PsyD: SouthEastern Fertility: Speakers Bureau
§ Shalini Gunawardena, RN, BSN: Walgreen's Nursing Advisory Board
§ Lee Higdon, PhD: Nothing to Disclose
§ Kristen Ivani, PhD: Nothing to Disclose
§ Sangita Jindal, PhD: Nothing to Disclose
§ Emily Jungheim, MD: Spouse is paid consultant: Abbvie, Genentech, Spectrum, Celgene; Speakers bureau: Genentech
§ Levent Keskintepe, DVM, PhD: Nothing to Disclose
§ Ann Kiessling, PhD: Nothing to Disclose
§ Rebecca Krisher, PhD: Grant/Research: Serono
§ Martin Langley, BS: Nothing to Disclose
§ Michael Lee, MS: Consultant: Cook Medical
§ Bruce Lessey, MD, PhD: Nothing to Disclose
§ Dennis Matt, PhD: Nothing to Disclose
§ David McCulloh, PhD: Consultant: Infertility and IVF Medical Associates of Western NY; ReproART; Biogenetics Corporation; Employee: NYU Langone Medical Center
§ Peter McGovern, MD: Nothing to Disclose
§ Yves Menezo, DSc, PhD: Consultant: Nurilia
§ Z. Peter Nagy, MD, PhD: Direct stockholder: My Egg Bank; Paid consultant: Origio, Fertilitech; Speakers bureau: Merck MSD
§ Mike Neal, MSc: Nothing to Disclose
§ Fariba Nehchiri, MSc: Nothing to Disclose
§ Sergio Oehninger, PhD: Nothing to Disclose
§ Kimball Pomeroy, PhD: Nothing to Disclose
§ Thomas (Rusty) Pool, PhD: Other: Auxogyn
§ Marc Portmann, MHA, MT: Nothing to Disclose
§ Catherine Racowsky, PhD: Consultant: Nora Therapeutics
§ Lisa Rinehart, JD: Nothing to Disclose
§ William Roudebush, PhD: Nothing to Disclose
§ Denny Sakkas, PhD: Consultant: Good Start Genetics; Other: Fertilitech, Origio
§ Mitchel Schiewe, PhD: Nothing to Disclose
§ Ira Sharlip, MD: Consultant: Pfizer, Lilly, Absorption, Vyrix
§ Scott Smith, PhD: Product Review: Biocoat
§ Amy Sparks, PhD: Nothing to Disclose
§ Laurel Stadtmauer, MD: Nothing to Disclose
§ Jason Swain, PhD: Consultant: Irvine Scientific
§ Tyl Taylor, MSc: Consultant; Spouse employed: Biodiseño
§ Helen Tempest, PhD: Nothing to Disclose
§ James Toner, MD, PhD: Speakers bureau: Merck
§ Nathan Treff, PhD: Nothing to Disclose
§ Tom Turner, MS: Nothing to Disclose
§ Matthew VerMilyea, PhD: Consultant: Auxogyn, Irvine Scientific, Genea Biomedx
§ Michael Vernon, PhD: Nothing to Disclose
§ Diane Wright, PhD: Nothing to Disclose
§ Hang Yin, PhD: Nothing to Disclose
It is the policy of the ASRM to ensure balance, independence, objectivity, and scientific rigor in all its educational activities. All faculty/authors participating in this activity were required to disclose any relationships they may have with commercial entities whose products or services are used to treat patients so that participants may evaluate the objectivity of the presentations. The content and views presented in this activity are those of the faculty/authors and do not necessarily reflect those of the ASRM. Any discussion of off-label, experimental, or investigational use of drugs or devices will also be disclosed. The disclosure statements were reviewed by the Subcommittee for Standards of Commercial Support of the CME Committee of ASRM and any perceived conflicts of interest were resolved in accordance with the policies of the ACCME.
STATEMENT OF SUPPORT
No commercial support has been provided for this activity.